Sunday, March 31, 2013

MIDEAST STOCKS-Saudi stocks inch higher in early trade

0818GMT- Saudi stocks open slightly higher in early trade on Saturday.

The all-share index rises 0.05 percent to 7178.75 points.

Al Rajhi Bank, the kingdom's largest listed lender, rises 0.38 percent. Saudi

Basic Industries Corp (SABIC), the world's biggest petrochemical company by market

value, is down 0.26 percent.

The banking index is up 0.13 percent and the petrochemicals index drops

0.13 percent.

Crude futures rose on Thursday, the last session of the first quarter, in choppy trading

with stronger Wall Street equities and a weaker dollar supporting dollar-denominated oil prices.

The S&P 500 set a record closing high on Thursday, finishing a fifth consecutive month of

gains to extend a four-year rally.

(Reporting by Reem Shamseddine; Editing by Angus McDowall)

Source: http://news.yahoo.com/mideast-stocks-saudi-stocks-inch-higher-early-trade-082415400--sector.html

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Scientists Built a Fake Virus Shell to Make a Sterile, Zombified Vaccine

Vaccines beef up your immune system by giving it a little taste of a weak—or dead—version of diseases. Now researchers in the UK have developed an alternative approach: build a synthetic doppelganger and let your body crush its hollow husk. More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/xPixb_YyLrU/scientists-scooped-out-virus-guts-to-make-a-sterile-zombified-vaccine

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Saturday, March 30, 2013

Parkinson's disease protein gums up garbage disposal system in cells

Friday, March 29, 2013

Clumps of ?-synuclein protein in nerve cells are hallmarks of many degenerative brain diseases, most notably Parkinson's disease.

"No one has been able to determine if Lewy bodies and Lewy neurites, hallmark pathologies in Parkinson's disease can be degraded," says Virginia Lee, PhD, director of the Center for Neurodegenerative Disease Research, at the Perelman School of Medicine, University of Pennsylvania.

"With the new neuron model system of Parkinson's disease pathologies our lab has developed recently, we demonstrated that these aberrant clumps in cells resist degradation as well as impair the function of the macroautophagy system, one of the major garbage disposal systems within the cell."

Macroautophagy, literally self eating, is the degradation of unnecessary or dysfunctional cellular bits and pieces by a compartment in the cell called the lysosome.

Lee, also a professor of Pathology and Laboratory Medicine, and colleagues published their results in the early online edition of the Journal of Biological Chemistry this week.

Alpha-synuclein (?-syn ) diseases all have clumps of the protein and include Parkinson's disease (PD), and array of related disorders: PD with dementia , dementia with Lewy bodies, and multiple system atrophy. In most of these, ?-syn forms insoluble aggregates of stringy fibrils that accumulate in the cell body and extensions of neurons.

These unwanted ?-syn clumps are modified by abnormal attachments of many phosphate chemical groups as well as by the protein ubiquitin, a molecular tag for degradation. They are widely distributed in the central nervous system, where they are associated with neuron loss.

Using cell models in which intracellular ?-syn clumps accumulate after taking up synthetic ?-syn fibrils, the team showed that ?-syn inclusions cannot be degraded, even though they are located near the lysosome and the proteasome, another type of garbage disposal in the cell.

The ?-syn aggregates persist even after soluble ?-syn levels within the cell are substantially reduced, suggesting that once formed, the ?-syn inclusions are resistant to being cleared. What's more, they found that ?-syn aggregates impair the overall autophagy degradative process by delaying the maturation of autophagy machines known as autophagosomes, which may contribute to the increased cell death seen in clump-filled nerve cells. Understanding the impact of ?-syn aggregates on autophagy may help elucidate therapies for ?-syn-related neurodegeneration.

###

University of Pennsylvania School of Medicine: http://www.uphs.upenn.edu/news/

Thanks to University of Pennsylvania School of Medicine for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/127519/Parkinson_s_disease_protein_gums_up_garbage_disposal_system_in_cells

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What advances are driving clinical applications of tissue engineering and regenerative medicine?

What advances are driving clinical applications of tissue engineering and regenerative medicine? [ Back to EurekAlert! ] Public release date: 29-Mar-2013
[ | E-mail | Share Share ]

Contact: Vicki Cohn
vcohn@liebertpub.com
914-740-2100 x2156
Mary Ann Liebert, Inc./Genetic Engineering News

New Rochelle, NY, Mar 28, 2013Explosive growth in the field of tissue engineering and regenerative medicine has led to innovative and promising applications and techniques, many of which are now being tested in human clinical trials. Hot topics, research advances, and transformative publications that are driving the field forward are highlighted in a comprehensive overview of the field presented in Tissue Engineering, Part B, Reviews, a peer-reviewed journal from Mary Ann Liebert, Inc. publishers (http://www.liebertpub.com). The article is available on the Tissue Engineering website (http://www.liebertpub.com/ten).

Matthew Fisher, PhD and Robert Mauck, PhD, Perelman School of Medicine, University of Pennsylvania, and Philadelphia Veterans Administration Medical Center, Philadelphia, PA, identify four key areas in which the field is progressing. The first main theme, in the area of tissue engineering, focuses on advances in grafts and materials, including human or animal tissue from which the cells are removed and the remaining scaffold is used to regenerate new tissues, as well as scaffolds made of new types of biomaterials. Second, in the field of regenerative medicine, the authors highlight the role of novel scaffolds and various growth and control factors in promoting tissue formation and, for example, bone healing.

In the article "Tissue Engineering and Regenerative Medicine: Recent Innovations and the Transition to Translation," (http://online.liebertpub.com/doi/full/10.1089/ten.teb.2012.0723) the authors identify two additional areas that signal progress in the field: the increasing number of applications advancing into clinical trials; and the growing use of novel types of cells, such as induced pluripotent stem cells.

"Considering the rapid pace of growth and development in regenerative medicine, it is imperative that we fully consider recent advances," says Reviews Co-Editor-in-Chief John P. Fisher, PhD, Professor and Associate Chair, Fischell Department of Bioengineering, University of Maryland, College Park, MD. "Dr. Matthew Fisher and Dr. Robert Mauck have wonderfully reviewed the efforts in the tissue engineering field over the past few years, highlighting advances in biomaterials, cell-based constructs, and translational endeavors."

###

About the Journal

Tissue Engineering is an authoritative peer-reviewed journal published monthly in print and online in three parts: Part A--the flagship journal; Part BReviews; and Part CMethods. Led by Co-Editors-In-Chief Antonios Mikos, PhD, Louis Calder Professor at Rice University, Houston, TX, and Peter C. Johnson, MD, Vice President, Research and Development, Avery Dennison Medical Solutions of Chicago, IL and President and CEO, Scintellix, LLC, Raleigh, NC, the Journal brings together scientific and medical experts in the fields of biomedical engineering, material science, molecular and cellular biology, and genetic engineering. Tissue Engineering is the Official Journal of the Tissue Engineering & Regenerative Medicine International Society (TERMIS). Complete tables of content and a sample issue may be viewed on the Tissue Engineering website (http://www.liebertpub.com/ten).

About the Publisher

Mary Ann Liebert, Inc. publishers, is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including Stem Cells and Development, Human Gene Therapy and HGT Methods, and Advances in Wound Care. Its biotechnology trade magazine, Genetic Engineering & Biotechnology News (GEN), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 70 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc. publishers website (http://www.liebertpub.com).

Mary Ann Liebert, Inc. 140 Huguenot St., New Rochelle, NY 10801-5215 http://www.liebertpub.com
Phone: (914) 740-2100 (800) M-LIEBERT Fax: (914) 740-2101


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


What advances are driving clinical applications of tissue engineering and regenerative medicine? [ Back to EurekAlert! ] Public release date: 29-Mar-2013
[ | E-mail | Share Share ]

Contact: Vicki Cohn
vcohn@liebertpub.com
914-740-2100 x2156
Mary Ann Liebert, Inc./Genetic Engineering News

New Rochelle, NY, Mar 28, 2013Explosive growth in the field of tissue engineering and regenerative medicine has led to innovative and promising applications and techniques, many of which are now being tested in human clinical trials. Hot topics, research advances, and transformative publications that are driving the field forward are highlighted in a comprehensive overview of the field presented in Tissue Engineering, Part B, Reviews, a peer-reviewed journal from Mary Ann Liebert, Inc. publishers (http://www.liebertpub.com). The article is available on the Tissue Engineering website (http://www.liebertpub.com/ten).

Matthew Fisher, PhD and Robert Mauck, PhD, Perelman School of Medicine, University of Pennsylvania, and Philadelphia Veterans Administration Medical Center, Philadelphia, PA, identify four key areas in which the field is progressing. The first main theme, in the area of tissue engineering, focuses on advances in grafts and materials, including human or animal tissue from which the cells are removed and the remaining scaffold is used to regenerate new tissues, as well as scaffolds made of new types of biomaterials. Second, in the field of regenerative medicine, the authors highlight the role of novel scaffolds and various growth and control factors in promoting tissue formation and, for example, bone healing.

In the article "Tissue Engineering and Regenerative Medicine: Recent Innovations and the Transition to Translation," (http://online.liebertpub.com/doi/full/10.1089/ten.teb.2012.0723) the authors identify two additional areas that signal progress in the field: the increasing number of applications advancing into clinical trials; and the growing use of novel types of cells, such as induced pluripotent stem cells.

"Considering the rapid pace of growth and development in regenerative medicine, it is imperative that we fully consider recent advances," says Reviews Co-Editor-in-Chief John P. Fisher, PhD, Professor and Associate Chair, Fischell Department of Bioengineering, University of Maryland, College Park, MD. "Dr. Matthew Fisher and Dr. Robert Mauck have wonderfully reviewed the efforts in the tissue engineering field over the past few years, highlighting advances in biomaterials, cell-based constructs, and translational endeavors."

###

About the Journal

Tissue Engineering is an authoritative peer-reviewed journal published monthly in print and online in three parts: Part A--the flagship journal; Part BReviews; and Part CMethods. Led by Co-Editors-In-Chief Antonios Mikos, PhD, Louis Calder Professor at Rice University, Houston, TX, and Peter C. Johnson, MD, Vice President, Research and Development, Avery Dennison Medical Solutions of Chicago, IL and President and CEO, Scintellix, LLC, Raleigh, NC, the Journal brings together scientific and medical experts in the fields of biomedical engineering, material science, molecular and cellular biology, and genetic engineering. Tissue Engineering is the Official Journal of the Tissue Engineering & Regenerative Medicine International Society (TERMIS). Complete tables of content and a sample issue may be viewed on the Tissue Engineering website (http://www.liebertpub.com/ten).

About the Publisher

Mary Ann Liebert, Inc. publishers, is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including Stem Cells and Development, Human Gene Therapy and HGT Methods, and Advances in Wound Care. Its biotechnology trade magazine, Genetic Engineering & Biotechnology News (GEN), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 70 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc. publishers website (http://www.liebertpub.com).

Mary Ann Liebert, Inc. 140 Huguenot St., New Rochelle, NY 10801-5215 http://www.liebertpub.com
Phone: (914) 740-2100 (800) M-LIEBERT Fax: (914) 740-2101


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-03/mali-wa032913.php

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95% West of Memphis

All Critics (106) | Top Critics (24) | Fresh (101) | Rotten (5)

A real-life horror story, made no less shocking by the familiarity of its early scenes.

While the "Paradise Lost" films captured events as they unfolded in the heat of battle, "West of Memphis" has the luxury of at least partial closure.

A true-crime story that begins with a notorious murder case and grows into a chilling indictment of the American justice system.

And justice for all? Hardly.

It tells the story of a terrible crime compounded by a grave injustice that's been remedied, but only in part, so it's impossible to have a single or simple response to the movie.

What sets this film apart from previous efforts to document the story is that Jackson and Walsh financed a private investigative team with legal and forensic experts who re-examined old evidence, conducted new interviews and found new witnesses.

The film is so utterly transfixing you won't believe almost two-and-a-half hours have passed when the final credits roll.

We feel like we're watching an overlong true-crime television episode and not a movie.

I would have preferred Jackson's clinically-presented project display a bit more reverence for the three young lives that were brutally taken some twenty years ago.

Moving and gruesome, West of Memphis is an eloquent disquisition on the banality of evil.

"West of Memphis" re-examines evidence and retells the story in a methodical and procedural fashion in which even the false steps lead somewhere.

More a recap and appendix to the Paradise Lost trilogy... one can't help but feel that the celebrities involved needed this document of their efforts to appease their vanity.

The case is more intriguing than the film about it.

Isn't unnecessary, but it's often superfluous.

The film suggests these powerless, poorly educated young men were scapegoated because they would be missed by nobody of importance -- the justice system equivalent of the cannon fodder recruited from the same socioeconomic straits.

It's nice to have all the twists and turns of the iconic case contained tidily in one well-crafted film, although there are no real revelations here.

"West of Memphis" becomes a greatest-hits concert of prosecutorial misconduct, and you'll agree when the film asserts that prosecutors knew they had the wrong guys.

Incredibly, after three documentaries on the subject, there are still things to reveal about the West Memphis Three.

"West of Memphis" does nothing to displace its predecessor films as masterpieces of investigative filmmaking, but complements them as a riveting capstone to an epic and tragic tale.

West of Memphis is the real vindication - even if it is incomplete.

In the end it won't matter if this is the fourth movie about the same subject; you can never learn its lessons often enough.

West of Memphis caps off the Paradise Lost/West Memphis Three saga with a line up full of perpetrators including the media, the West Memphis PD, the legal establishment and suspect gift wrapped with a smoking gun.

Injustice in West Memphis, Arkansas

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Source: http://www.rottentomatoes.com/m/west_of_memphis/

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Microsoft showcases Windows Phone middleware partnerships at GDC, we go hands-on (video)

Microsoft demoes Windows Phone middleware partnerships at GDC, we go handson video

Building on yesterday's announcement that Temple Run and several other games are coming to Windows Phone, Microsoft's been actively courting developers at GDC 2013. To that end, the company's booth showcases several games that highlight cross-platform development and middleware. Now that WP8 and Windows 8 share the same NT kernel, DirectX APIs and tools, it's easier than ever to write games that use the same code base for both platforms. Microsoft is sweetening the deal with a few significant middleware partnerships -- Unity, Marmalade and Havok, to be specific. We talked with Larry Lieberman, Senior Product Manager for Windows Phone development, who was kind enough to explain what these partnerships mean for developers and to give us a tour of the games. Hit the break for our hands-on video.

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/RMoP53fp7Sk/

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Friday, March 29, 2013

The Secret Republican Plan to Repeal 'Obamacare'

A few minutes after the Supreme Court issued its landmark decision upholding President Obama?s health care law last summer, a senior adviser to Mitch McConnell walked into the Senate Republican leader?s office to gauge his reaction.

McConnell was clearly disappointed, and for good reason. For many conservatives, the decision was the death knell in a three-year fight to defeat reforms that epitomized everything they thought was wrong with Obama?s governing philosophy. But where some saw finality, McConnell saw opportunity ? and still does.

Sitting at his desk a stone?s throw from the Senate chamber, McConnell turned to the aide and, with characteristic directness, said: ?This decision is too cute. But I think we got something with this tax issue.?

He was referring to the court?s ruling that the heart of the 2010 Affordable Care Act, the so-called individual mandate that requires everyone in the country to buy health insurance or pay a penalty, was a tax. And while McConnell thought calling the mandate a tax was ?a rather creative way? to uphold the law, it also opened a new front in his battle to repeal it.

McConnell, a master of byzantine Senate procedure, immediately realized that, as a tax, the individual mandate would be subject to the budget reconciliation process, which exempted it from the filibuster. In other words, McConnell had just struck upon how to repeal Obamacare with a simple majority vote.

The Kentucky Republican called a handful of top aides into his office and told them, ?Figure out how to repeal this through reconciliation. I want to do this.? McConnell ordered a repeal plan ready in the event the GOP took back control of the Senate in November ? ironic considering Democrats used the same process more than two years earlier in a successful, last-shot effort to muscle the reforms into law.

In the months that followed, top GOP Senate aides held regular strategy meetings to plot a path forward. Using the reconciliation process would be complicated and contentious. Senate rules would require Republicans to demonstrate to the parliamentarian that their repeal provisions would affect spending or revenue and Democrats were sure to challenge them every step of the way. So the meetings were small and secret.

?You?re going in to make an argument. You don?t want to preview your entire argument to the other side ahead of time,? said a McConnell aide who participated in the planning. ?There was concern that all of this would leak out.?

By Election Day, Senate Republicans were ready to, as McConnell put it, ?take this monstrosity down.?

?We were prepared to do that had we had the votes to do it after the election. Well, the election didn?t turn out the way we wanted it to,? McConnell told National Journal in an interview. ?The monstrosity has ... begun to be implemented and we?re not giving up the fight.?

Indeed, when it comes to legislative strategy, McConnell plays long ball. Beginning in 2009, the Republican leader led the push to unify his colleagues against Democrats? health care plans, an effort that almost derailed Obamacare. In 2010, Republicans, helped in part by public opposition to the law, won back the House and picked up seats in the Senate. Last year, GOP presidential nominee Mitt Romney?s embrace of the individual mandate while Massachusetts governor largely neutralized what had been a potent political issue.

But, in the next two years, Republicans are looking to bring the issue back in a big way. And they?ll start by trying to brand the law as one that costs too much and is not working as promised.

Democrats will be tempted to continue to write off the incoming fire as the empty rhetoric of a party fighting old battles. But that would be a mistake. During the health care debate, the GOP?s coordinated attacks helped turn public opinion against reform. And in the past two years, no more than 45 percent of the public has viewed Obamacare favorably, according to the Kaiser Family Foundation?s tracking polls. Perhaps even more dangerous for Democrats, now-debunked myths spread by Republicans and conservative media remain lodged in the public consciousness. For instance, 40 percent of the public still believes the law includes ?death panels.?

During the legislative debate over the law, Democrats promised Obamacare would create jobs, lower health care costs, and allow people to keep their current plans if they chose to. Those vows, Republicans argue, are already being broken.

The Congressional Budget Office, the Hill?s nonpartisan scorekeeper, estimated that the health care law would reduce employment by about 800,000 workers and result in about 7 million people losing their employer-sponsored health care over a decade. The CBO also estimated that Obamacare during that period would raise health care spending by roughly $580 billion.

McConnell?s office has assembled the law?s 19,842 new regulations into a stack that is 7 feet high and wheeled around on a dolly. The prop even has its own Twitter account, @TheRedTapeTower.

?All you got to do is look at that high stack of regulation and you think, ?How in the world is anybody going to be able to comply with all this stuff?? ? GOP Sen. Orrin Hatch, told National Journal. ?And I?m confident that the more the American people know of the costs, the consequences, the problems with this law, then someday there are going to be some Democrats who are going to join us in taking apart some of its most egregious parts.?

In fact, just a few hours after that interview last week, 34 Democrats joined Hatch on the Senate floor to support repealing Obamacare?s medical-device tax. Though the provision passed overwhelmingly, it doesn?t have a shot at becoming law because the budget bill it was attached to is nonbinding. Still, Republicans see it as a harbinger of things to come.

?Constituent pressure is overriding the view that virtually all Democrats have had that Obamacare is sort of like the Ten Commandments, handed down and every piece of it is sacred and you can?t possibly change any of it ever,? McConnell said. ?When you see that begin to crack then you know the facade is breaking up.?

Of course, Republicans are doing their best to highlight and stoke the kind of constituent anger that would force Democrats to tweak the law. In fact, if Democrats come under enough pressure, Republicans believe they might be able to inject Obamacare into the broader entitlement-reform discussion they are planning to tie to the debt-limit debate this summer.

But that is a long shot. If Republicans hope to completely repeal the health care law, they have to start by taking back the Senate in 2014 and would likely need to win the White House two years later. Still, some Republicans think the politics are on their side.

?I?m not one of those folks who ... because I didn?t support something, I want it to be bad. I want good things for Americans. But I do think this is going to create a lot of issues and ? affect things throughout 2014 as it relates to politics,? Republican Sen. Bob Corker said. ?The outcome likely will create a better atmosphere for us.?

Republicans will need to win half a dozen seats to retake the chamber. So, what are the chances??

?There are six really good opportunities in really red states: West Virginia, North Carolina, Louisiana, Arkansas, South Dakota, and Alaska,? McConnell said last week. ?And some other places where you have open seats like Michigan and Iowa. And other states that frequently vote Republican, an example of that would be New Hampshire. So, we?re hopeful.?

And earlier this week, Democratic Sen. Tim Johnson put his home state of South Dakota in play when he announced he will not be running for reelection in 2014.

In addition to trying to win back the Senate, McConnell will have to protect his own seat in two years. McConnell has made moves to shore up his right flank to fend off conservative challengers. He?s hired fellow Kentucky Republican Sen. Rand Paul?s campaign manager, who helped Paul defeat the establishment candidate McConnell backed in the primary. ?

In the meantime, Republicans will continue to, as GOP Sen. John Barrasso put it, ?try to tear (Obamacare) apart.? And the GOP suspects it might get some help from moderate Democrats less concerned about protecting Obama?s legacy than winning reelection.

It?s just the latest act in a play that saw McConnell give more than 100 floor speeches critical of Democratic reforms and paper Capitol Hill with more 225 messaging documents in the 10 months before Obamacare?s passage. Away from the public spotlight, McConnell worked his caucus hard to convince them to unite against the law, holding a health care meeting every Wednesday afternoon. GOP aides said they could not remember a time before, or since, when a Republican leader held a weekly meeting with members that focused solely on one subject.

?What I tried to do is just guide the discussion to the point where everybody realized there wasn?t any part of this we wanted to have any ownership of,? McConnell recounted. ?That was a nine-month long discussion that finally culminated with Olympia Snowe?s decision in the fall not to support it. She was the last one they had a shot at.?

Indeed, some Republicans remember opposition forming organically as it became clearer where Democrats were headed, crediting McConnell for crystallizing the issue. Asked who unified Senate Republicans against Obamacare, Corker recalled, ?I think it happened over time.? As time moved on, it just seemed that this train was going to a place that was going to be hard to support.?

McConnell had finally won his long-fought battle to unite the conference against Obamcare. And some Republicans credit McConnell with being first to that fight.

?He had the Obama administration?s number before almost anyone else,? Hatch recalled. ?He began laying the groundwork for this fight very early, in private meetings and so forth, and really was the first one on our side in the ring, throwing punches just about how bad it was for families, businesses, and our economy.?

?There?s been no stronger fighter against this disastrous law than Mitch McConnell,? he added.

And as McConnell?s war continues, Democrats have begun positioning themselves for the next battle. Leading up to last week?s three-year anniversary of the law?s passage, Democrats held press events touting its benefits, claiming more than 100 million people have received free preventive services; 17 million children with preexisting conditions have been protected from being denied coverage; and 6.6 million young adults under 26 have been covered by their parents' plan.

Democrats wisely rolled out many of the easiest, most-popular Obamacare benefits first. The next few years will see the implementation of provisions that are both more complicated and controversial, like creating state-based insurance exchanges where people can buy coverage. Asked about the political ramifications of possible implementation problems, Democratic Sen. Max Baucus, a chief architect of Obamacare, sidestepped the question saying, "My job is to do my best to make sure this statute works to help provide health care for people at the lowest possible cost."

Far from a full-throated assurance that everything will run smoothly, Baucus?s answer hints at the dangers Democrats face as Obamacare comes online.

And with the law moving from the largely theoretical to the demonstrable, the health care debate is poised to return to intensity levels not seen since before the law passed.

For congressional Republicans, it?s probably their last, best chance to turn opposition into political gain.

And much of that job falls to McConnell, a brilliant defensive coordinator who will have to play flawless offense if he hopes to take control of the Senate next year.

Source: http://news.yahoo.com/secret-republican-plan-repeal-obamacare-200403420--politics.html

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Samsung Galaxy S 4 mini will reportedly go on sale shortly after GS 4

Samsung Galaxy S 4 mini will reportedly go on sale shortly after GS 4

Not too long after the Samsung Galaxy S 4 was announced, we started hearing whispers of a "miniature" version of the device -- which makes sense, given the Galaxy S III had a smaller sidekick of its own. Today, however, Bloomberg reported the unannounced device is indeed coming soon after the flagship makes its appearance at the end of April. If it follows a similar pattern to its bite-sized predecessor, it likely will be offered in Europe as a lower-cost alternative to the Galaxy S 4. The device is rumored to offer a dual-core 1.6GHz processor, a 4.3-inch display and 8MP camera. Sadly, no official details were given, but we've reached out to Samsung officials for comment and will update when we receive word.

Update: Samsung pinged back with the following comment, which doesn't do much towards confirming or denying whether or not the GS 4 mini is indeed on the horizon. A spokesperson informed us: "We have not announced the product mentioned in the Bloomberg story."

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Via: SamMobile, 9to5Google

Source: Bloomberg

Source: http://www.engadget.com/2013/03/28/samsung-galaxy-s-4-mini/

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North Korea's 3G Experiment Might Be Over

North Korea's Internet liberation has hit a snag -- it's still North Korea. One month after announcing that it would grant tourists and visitors 3G Internet access, North Korea appears to have revoked its 3G services. Tourists reportedly no longer have 3G access. There is a chance that the 3G service is merely busted, but given North Korea's history, the consensus at the moment is that the plug has been pulled.

Source: http://ectnews.com.feedsportal.com/c/34520/f/632000/s/2a0f169e/l/0L0Stechnewsworld0N0Crsstory0C776380Bhtml/story01.htm

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Google Android 4.2.2 'Jelly Bean'


Android 4.2.2 "Jelly Bean" is Google's latest refinement of what is now the world's most popular OS on new smartphones. For now, you can only get Android 4.2.2 on a few devices, including the?Google Nexus 4 phone, and the Google Nexus 7 and Nexus 10 tablets. It's also rolling out to existing Galaxy Nexus owners, and the newly announced Samsung Galaxy S4 will have it at launch. There's nothing revolutionary about Android 4.2.2, but there are enough significant updates to cement Jelly Bean's Editors' Choice status for mobile smartphone operating systems.

User Interface Improvements
For this review, I tested Android 4.2.2 on a Google Nexus 4. As was the case with Android 4.1, the setup process is smooth, and faster than it is with earlier Android phones. Most of the default options were already checked, for example, and I had no problem adding my existing Google account. Once you're in, the OS walks you along with a series of translucent tip screens that appear over the home screen and main menu. This hand-holding is definitely helpful if you're new to the OS, though experienced users will already know many of the tips.

As we found when first testing Android 4.1, there's more going on here than just minor UI refinements. At Google I/O last year, Google engineering director David Burke talked about Project Butter, which was the company's effort to improve Android performance enough that it feels "buttery" smooth in use. This effort affected many aspects of the OS, such as improved vsync timing for faster frame rates on the display itself, triple graphics buffering for preventing dropped frames in video games, and improved overall touch-screen response.

In practice, there's definitely a noticeable improvement over, say, Android 4.0 "Ice Cream Sandwich." You can easily resize and move around icons and widgets on each home screen panel or delete apps by swiping the icon up, which causes it to disappear. The system font ("Roboto") already looked sharp and smooth before, and still does. But menu animations, finger swipes, and scrolling feel at least as solid as they do on iOS, if not better.

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Keyboard, Web Browser, and Messaging
The predictive keyboard works well. I spent quite some time typing on it, and it seemed to do a much better job than before at guessing the word I meant, even whenever I typed several letters incorrectly. The prediction function works just as it does on Apple iOS 6.1, in that it can figure out what word you want to type even if your fingers are not hitting the on-screen keys directly, just by the grammar of your sentence and the built-in dictionary.

For the Swype-inclined, the new?Gesture Typing feature attempts to mimic Swype, in that you can now draw out words by gliding your fingertip over each letter on the on-screen keyboard. Google also boosted the predictive text engine to allow for spaces between words, as well as boosting the dictionary the engine uses overall, both for voice dictation and typing.

In fact, Android 4.2.2's predictive text engine also tops that of iOS, in that it still shows the bar beneath the text window with possible alternatives?rather than just one the way the iPhone does?and then pops it in with a little animated fade as you continue typing. These are small details, but they're beautiful in action. This is exactly the kind of polish Android needed all along, though the new BlackBerry Z10 on-screen keyboard has turned out to be even better.

The Web browser offers smooth handling of multiple tabs, which you can swipe among on a separate screen. One issue; while auto-rotate is switched off by default, when I turned it on, I noticed some pages had trouble formatting columns of text when flipping between landscape and portrait mode. In other words, the screen would be formatted correctly in one orientation, but then end up with a thin column and lots of white space in the other.

Adobe has officially dropped support for Flash starting with Jelly Bean 4.1. This doesn't bother me as much as it irks others. Even when it works on mobile devices, it doesn't really work all that well. The end of Flash for Android is hardly a surprise, at any rate, as Adobe said months ago it was discontinuing all mobile Flash development.

In the messaging app, tap the new message icon, and it pops up names and photos from your contact list as you type letters, including alternate phone numbers indented slightly as compared with the main one. I tested this function with a book of about 1,500 contacts and it was super fast.

Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/T62K9UgA44Y/0,2817,2406539,00.asp

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Thursday, March 28, 2013

HomeVestors Continues Aggressive Trademark Enforcement in First ...

HomeVestors Franchise Continues Diligence in Protecting its Trademarks?

DALLAS - March 27, 2013 // PRNewswire // - HomeVestors of America, Inc. ("HomeVestors"), known for its registered trademark We Buy Ugly Houses?, has been diligent in protecting its trademarks. Since its incorporation in 1996, HomeVestors has aggressively defended its federally registered trademarks and enforced its right to prevent third parties from infringing these marks, in third-party websites, domain names, and in keyword advertising.

In the first quarter of 2013 alone, HomeVestors has initiated enforcement action against as many as fourteen new third-party infringers and has already secured victory in five matters. HomeVestors is also pursuing a number of Uniform Domain-Name Dispute-Resolution Policy ("UDRP") proceedings against parties that are incorporating HomeVestors trademarks into domain names. HomeVestors also continues to see an increase in third-party use of the federally registered HOMEVESTORS? mark, or confusingly similar variations thereof, an indication that the HOMEVESTORS? brand continues to grow and gain strength and recognition throughout the United States. HomeVestors is, of course, diligently pursuing those matters as well.

HomeVestors is the #1 buyer of houses in the U.S. The first franchise company of its kind, HomeVestors has been franchising since 1996. HomeVestors currently has over 300 independently owned and operated franchises in 37 states. Franchisees are authorized to use the WE BUY UGLY HOUSES? and HOMEVESTORS? trademarks in connection with their franchised business. Use of such trademarks by unauthorized third parties, however, is prohibited.

"HomeVestors continues to aggressively pursue infringers of both its WE BUY UGLY HOUSES? and HOMEVESTORS? marks," explained HomeVestors litigation attorney Darin Klemchuk of Klemchuk Kubasta LLP. "It will continue to pursue every infringement of which it becomes aware in order to maintain the vast goodwill and national recognition in its marks."

HomeVestors has owned and used the HOMEVESTORS?, WE BUY UGLY HOUSES?, the UG? family of marks, and other proprietary trademarks continuously for many years. Over the years, HomeVestors has spent significant amounts of time and resources in developing its brand and maintaining the goodwill it has built in its trademarks.

About HomeVestors of America, Inc.

Dallas-based HomeVestors of America, Inc. is the #1 buyer of houses in the U.S. HomeVestors trains and supports franchisees that specialize in buying and rehabbing residential properties. Most commonly known as the "We Buy Ugly Houses" company, HomeVestors strives to make a positive impact in each community. In 2012, for the seventh consecutive year, HomeVestors was among the prestigious Franchise Business Review's "Top 50 Franchises," a distinction awarded to franchisers with the highest level of franchisee satisfaction. For more information, visit www.HomeVestors.com.

About Klemchuk Kubasta LLP

Klemchuk Kubasta LLP is a law firm offering a full array of intellectual property related services, including litigation and enforcement of all forms of intellectual property, as well as registration and licensing of patents, trademarks, trade dress, and copyrights. The firm also provides legal services relating to trade secrets, unfair competition, domain names, e-commerce, privacy policies, Internet law, commercial and business litigation, technology transactions, and international business and trade. Located in Dallas, Texas, Klemchuk Kubasta LLP supports a diverse client base ranging from startups to established market-leading companies. Klemchuk Kubasta LLP also serves as local counsel for IP and commercial litigation cases pending in Texas, including the federal courts in the Northern and Eastern Districts of Texas. Additional information about the firm and its attorneys may be found at www.kk-llp.com.

Contact:

Calise Partners
Susie Lomelino
slomelino@calisepartners.com
214.564.3285

SOURCE HomeVestors of America, Inc.

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Source: http://www.franchising.com/news/20130327_homevestors_continues_aggressive_trademark_enforce.html

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David Whitney Building, Detroit Landmark, To Be Renovated With Aloft Hotel, Apartments, Restaurants (PHOTOS)

A soaring historic building in Detroit, long empty, is on its way to a new life.

When the $82 million renovation of the David Whitney at Woodward Avenue and Grand Circus Park is completed in July 2014, the 19-story building will house the city's first boutique hotel, restaurants and bar, apartments and a connection to downtown public transportation.

"This project has so much more context than just ... the redevelopment of a historic gem," Dave Blaszkiewicz of the Downtown Detroit Partnership said Thursday. "The Davids, the Broderick Tower and the David Whitney building, are the gateways to our central business community."

(SCROLL DOWN FOR PHOTOS)

The project, years in the making, is headed up by Whitney Partners LLC. It's a partnership of Detroit real estate developers the Roxbury Group and hotel management company Trans Inns Management. The company was joined by the Detroit Economic Growth Corporation, Bank of America Michigan, the Downtown Detroit Partnership and Gov. Rick Snyder for an unorthodox start to construction Thursday morning. In lieu of a traditional groundbreaking, Snyder flipped a massive metal lever to switch on interior lights.

"For how many years, people might have stood here and said, 'this is a problem,'" the governor said. "This was a problem for a lot of years. Now we're standing here today to say this is an opportunity ... for the future."

The ceremony took place on the building's ground floor, a central space also filled with light filtering in from far above. When renovations are complete, the space will be the lobby for Aloft, a boutique hotel chain under the parent company Starwood Hotels and Resorts Worldwide.

"Aloft [and Starwood] got it. They understood the potential of this space," said David Di Rita, Roxbury Group principal.

Aloft's first mixed-use project will have 136 rooms on the third through ninth floors, with suites on the third and fourth. The second floor will have banquet and meeting space looking into the building's large atrium. The 10th floor and above will contain 105 one- and two-bedroom residential apartments.

"We really said, let the hotel's needs drive this," explained Di Rita. "It just happened to work out that the right size for them took about half the building. And we said, 'great, we'll take the rest for residential,' because we know that will go."

On the ground floor, Aloft's WXYZ bar and re: mix lounge will fill the space along Woodward Avenue. On the building's Washington Avenue side, the Whitney Partners are planning a second restaurant to complement Aloft's offerings that will evoke the building's history, one of the driving forces in the project that includes restoration of interior finishes and exterior renovations to bring back elements of the original construction.

Originally the structure featured a classical exterior that included columns, but this changed when its owners hired the fim Harley, Ellington & Day to give it a more modern look in 1959.

A closed-off portion of the Grand Circus Park People Mover station on the second floor will be reopened, with new elevator and escalator access.

"Our view of it always was that this building needed to be more than a residential project, and whatever use we brought here had to really create a public space," said Di Rita.

The historic building, named for Detroit lumber baron David Whitney Jr., opened in 1915, but has sat empty since 2000. It was designed by the firm of the famed U.S. skyscraper architect Daniel Burnham, who was responsible for creating the Flatiron Building in New York City.

"A hundred years ago, when David C. Whitney placed a call to Daniel Burnham to design a building in his father's name, it was ... in some respects, I think, a city that has much in common with the city we live in today," Di Rita said. "Like today, it was a city of just over 700,000 people. Like today, it was a city brimming with entrepeneurs whose creativity defined its character. And like today, it was a city of visionary business and civic leaders who decided it was time for the world to know of Detroit's coming greatness."

While the construction project has a ways to go, the unrestored building still holds many interesting architectural details. Below, see pictures of the Whitney as it stands today, which gives a bit of a feel for what it can become.

  • The David Whitney building.

  • Gov. Rick Snyder flips the lever for the ceremonial interior lighting of the historic David Whitney building to celebrate the beginning of construction on the $82 million development project that will include retail, residential and hotel space.

  • Snyder flips the switch.

  • The lit interior of the historic David Whitney building.

  • Ornate clock in the David Whitney building.

  • Detail in the David Whitney building.

  • Staircase banister in the David Whitney building.

  • Gov. Rick Snyder speaks in the atrium of the David Whitney building, with historic images behind him.

  • The closed-off People Mover Grand Circus station entrance on the second floor of the David Whitney.

  • This space along the Woodward Avenue side of the David Whitney building will hold Aloft hotel's signature WXYZ bar and re: mix lounge.

  • This space along the Woodward Avenue side of the David Whitney building will hold Aloft hotel's signature WXYZ bar and re: mix lounge.

  • The space along Washington Boulevard will hold a restaurant planned by the Whitney Partners, who say it will evoke the David Whitney building's history.

  • The space along Washington Boulevard will hold a restaurant planned by the Whitney Partners, who say it will evoke the David Whitney building's history.

  • The space along Washington Boulevard will hold a restaurant planned by the Whitney Partners, who say it will evoke the David Whitney building's history.

  • The David Whitney building.

  • The David Whitney building interior from the second floor, looking to the closed-off entrance to the People Mover.

  • Interior detail in the David Whitney building.

  • In one of the rooms on the second floor of the David Whitney building, where Aloft hotel will have banquet and meeting space.

  • Looking a the People Mover stairs outside through a window on the second floor of the David Whitney building.

  • Second floor of the David Whitney Building.

  • Elevators in the David Whitney building.

  • Elevators in the David Whitney building.

  • An ornate mailbox on the first floor of the David Whitney building.

  • Looking down onto what will be Aloft's lobby.

  • Second floor of the David Whitney Building.

  • Second floor of the David Whitney Building.

  • The David Whitney building's spacious atrium.

  • The David Whitney building.

  • Gov. Rick Snyder speaks at the event kicking off construction on the David Whitney building.

  • David Whitney building, Washington Boulevard entrance.

  • Grand Circus People Mover station.

  • Detroit Economic Growth Corporation's George Jackson speaks at the event kicking off construction on the David Whitney building.

  • Downtown Detroit Partnership's Dave Blaszkiewicz speaks at the event kicking off construction on the David Whitney building.

  • Roxbury Group's David Di Rita speaks at the event kicking off construction on the David Whitney building.

  • Second floor space at the David Whitney building.

David Sands contributed to this report.

Also on HuffPost:

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Source: http://www.huffingtonpost.com/2013/03/28/david-whitney-building-renovation-hotel-detroit_n_2970968.html

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Soccer-Asian heavyweights lick wounds inflicted by underdogs

March 27 (Reuters) - Japan coach Alberto Zaccheroni was left to rue a profligate forward line as the Blue Samurai blew a chance to become the first team to qualify for the 2014 World Cup finals in Brazil.

Japan only needed to draw against a Jordan team they had thrashed 6-0 last June to secure a fifth consecutive finals appearance but were let down by poor finishing in a 2-1 reversal at Amman's King Abdullah International Stadium on Tuesday.

"We wanted to qualify for the World Cup (on Tuesday) and it is a real shame and we are all disappointed," Zaccheroni was quoted as saying by Kyodo news agency.

"We paid the price for not taking our chances. Our finishing has let us down again. We had about 10 chances and Jordan had three," the Italian added.

Shinji Kagawa, who scored Japan's goal, echoed the Italian's sentiments.

"We've lost and we are gutted," the Manchester United midfielder lamented after Japan wasted a golden opportunity to secure at least a point when Yasuhito Endo's 70th-minute penalty was brilliantly saved by Jordan keeper Amer Sabbah.

"We should have scored more goals and this game was there for the taking. We'll just have to better in our next game at home."

Japan, who lead Asia's Group B on 13 points from six matches, host Australia on June 4 and wrap up their campaign away to Iraq a week later.

A deeper gloom descended on the Australian camp after Holger Osieck's side rallied to salvage a 2-2 home draw against Oman to complicate their passage to Brazil.

Osieck fielded a side that lacked experience and urgency against Oman, leaving forward Tim Cahill slightly concerned over the remaining matches in the campaign.

"I asked for a high-tempo game. I don't want the ball thrown into the box all the time," said the 33-year-old New York Red Bulls striker, scorer of Australia's first goal and a constant aerial threat as the hosts piled on the pressure late on.

"So we'll learn as we go along but overall this is going to take time because there's a lot of young players and inexperience.

"I'm happy for the youngsters that they're getting the experience but it's going to be a difficult run in to the campaign."

RESURGENT KOREA

In Seoul, a winning goal deep into injury time helped South Korea overcome Qatar 2-1 to revive their Group A campaign after managing just one point from their last two matches.

"It was a dramatic victory," Korean coach Choi Kang-hee said. "Because of the manner of victory, that gives the camp a lift going into the final games."

Korea occupy second spot in the group on 10 points from five games as they chase an eighth straight finals appearance.

"We know what we have to do to get to the World Cup and our desire to get there is strong. We have some rebuilding to do but at the moment the focus in on qualification," Choi added.

Group leaders Uzbekistan, on 11 points from six games, increased their hopes of securing a maiden World Cup finals appearance while virtually crushing Lebanon's hopes with a 1-0 victory over the West Asians.

"It was a difficult match and we had to fight in every part of the field. Lebanon played well in the first half and they didn't make any mistakes in defence," Uzbekistan coach Mirdjalal Kasimov said.

"We tried our best against Uzbekistan... but they were the better team," Lebanon coach Theo Bucker said.

"We are playing in the final round of qualifying for the World Cup and that is an achievement for us." (Reporting by Amlan Chakraborty in New Delhi; Editing by John O'Brien)

Source: http://news.yahoo.com/soccer-asian-heavyweights-lick-wounds-inflicted-underdogs-084940278--sow.html

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S&P nears record as home price surge lifts stocks

NEW YORK (AP) ? More good news on the economy Tuesday drove the Standard & Poor's 500 index to within two points of its record closing high.

The S&P rose 12.08 points, or 0.8 percent, to 1,563.77. Its record close of 1,565.16 was on Oct. 9, 2007, before the Great Recession and ensuing financial crisis battered markets.

Rising home prices and orders for manufactured goods drove all other major indexes higher as well. The Dow Jones industrial average rose 111.90 points, or 0.8 percent, to another record high ? 14,559.65.

"Unless something major comes along to derail this rally, it just seems like the market is going to keep climbing higher," said Marty LeClerc, the managing partner of Barrack Yard Advisors, an investment firm in Bryn Mawr, Pa.

Factory orders surged in February, helped by stronger demand for commercial aircraft. Overall orders for durable goods, a catchall term for products ranging from refrigerators to jumbo jets, jumped 5.7 percent from the previous month, the Commerce Department said Tuesday. It was the biggest increase in five months.

All 10 industry groups in the S&P 500 rose, led by health care and energy companies. But smaller companies, which have been beating the market all year, didn't do as well Tuesday. The Nasdaq composite rose 17.18 points, or 0.5 percent, to 3,252.48, and the Russell 2000 rose 3.97 points, or 0.4 percent, to 949.82.

Big-company stocks and small-company stocks often part ways, said Jack Ablin, chief investment officer at BMO Private Bank in Chicago. Recently, Europe has been the reason. Big corporations generally do more business in Europe, and their stocks had wavered over the past week as traders watched negotiations to rescue Cyprus.

After a deal was announced Sunday, there was still uncertainty on Wall Street Monday. But by Tuesday, investors seemed back to focusing on the U.S. economy, and stocks of big companies rose the most.

By contrast, smaller companies are less exposed to the rest of the world. "That's part of the reason small-caps have outpaced the market this year," Ablin said. The Russell 2000 is up 11.8 percent this year, compared with 9.7 percent for the S&P 500.

European markets rose modestly as investors gained confidence in the new bailout plan arranged for Cyprus and its banking system. Cyprus decided to keep its banks closed for another two days in an attempt to ward off panicked withdrawals.

Netflix surged 5 percent, leading the S&P 500, after an analyst at Pacific Crest Securities said the stock will likely climb as the company continues to add subscribers. Netflix's database of its members' viewing habits should give it an edge in creating shows and draw more people to sign up for its video-streaming service, the analyst said. Netflix rose $9.82 to $190.61.

Housing prices rose in January at the fastest pace since the summer of 2006, before the housing bubble popped. The Standard & Poor's/Case-Shiller index of prices in 20 cities was up 8.1 percent over January 2012. That compared with a 6.8 percent year-over-year increase in the index in December. Prices rose in all 20 cities, led by 23.2 percent in Phoenix and 17.5 percent in San Francisco.

The economic reports out Tuesday added to evidence that the economy is slowly improving, and that's what many investors want right now, LeClerc said. Slow growth and continued low inflation mean it could be a long time before the Federal Reserve starts unraveling its bond-buying program and raising interest rates.

In the market for U.S. government bonds, the yield on the 10-year Treasury note slipped to 1.91 percent from 1.92 percent late Monday.

Among other stocks making big moves Tuesday:

? Drive-in restaurant chain Sonic jumped 10 percent after reporting that its quarterly earnings more than doubled. Revenue was flat, but Sonic said it expects improvement. Its stock rose $1.14 to $12.87.

? Supervalu rose after announcing plans to lay off more than 1,000 people, roughly 3 percent of its workforce. The supermarket operator said its recent sale of five grocery chains means it needs fewer workers. Supervalu's stock gained 7 cents, or 1.4 percent, to $5.12.

? Children's Place Retail Stores sank 3 percent after the company reported weaker quarterly earnings. The retailer also said bad weather would crimp revenue. The company's stock lost $1.48 to $44.51.

Source: http://news.yahoo.com/p-nears-record-home-price-surge-lifts-stocks-205255060--finance.html

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Tuesday, March 26, 2013

Rights groups fears for hunger strikers in Bahrain

Mar 26 (Reuters) - Leading money winners on the 2013 PGATour on Monday (U.S. unless stated): 1. Tiger Woods $3,787,600 2. Brandt Snedeker $2,859,920 3. Matt Kuchar $2,154,500 4. Steve Stricker $1,820,000 5. Phil Mickelson $1,650,260 6. Hunter Mahan $1,553,965 7. John Merrick $1,343,514 8. Dustin Johnson $1,330,507 9. Russell Henley $1,313,280 10. Kevin Streelman $1,310,343 11. Keegan Bradley $1,274,593 12. Charles Howell III $1,256,373 13. Michael Thompson $1,254,669 14. Brian Gay $1,171,721 15. Justin Rose $1,155,550 16. Jason Day $1,115,565 17. Chris Kirk $1,097,053 18. ...

Source: http://news.yahoo.com/rights-groups-fears-hunger-strikers-bahrain-115422989.html

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Functional ovarian tissue engineered in lab

Mar. 26, 2013 ? A proof-of-concept study suggests the possibility of engineering artificial ovaries in the lab to provide a more natural option for hormone replacement therapy for women. In Biomaterials, a team from Wake Forest Baptist Medical Center's Institute for Regenerative Medicine report that in the laboratory setting, engineered ovaries showed sustained release of the sex hormones estrogen and progesterone.

Although there are medications that can compensate for the loss of female sex hormone production, the drugs are often not recommended for long-term use due to the increased risk of heart disease and breast cancer.

"Our goal is to develop a tissue- or cell-based hormone therapy -- essentially an artificial ovary- to deliver sex hormones in a more natural manner than drugs," said Emmanuel C. Opara, Ph.D., professor of regenerative medicine and senior author. "A bioartificial ovary has the potential to secrete hormones in a natural way based on the body's needs, rather than the patient taking a specific dose of drugs each day."

Ovaries are the female reproductive organs that produce eggs that are fertilized for pregnancy as well as secrete hormones important to bone and cardiovascular health. The loss of ovarian function can be due to surgical removal, chemotherapy and radiation treatments for certain types of cancer, and menopause. The effects of hormone loss can range from hot flashes and vaginal dryness to infertility and increased risk of osteoporosis and heart disease.

"This research project is interesting because it offers hope to replace natural ovarian hormones in women with premature ovarian failure or in women going through menopause," Tamer Yalcinkaya, M.D., associate professor and section head of reproductive medicine at Wake Forest Baptist. "The graft format would bring certain advantages: it would eliminate pharmacokinetic variations of hormones when administered as drugs and would also allow body's feedback mechanisms to control the release of ovarian hormones."

The project to engineer a bioartificial ovary involves encapsulating ovarian cells inside a thin membrane that allows oxygen and nutrients to enter the capsule, but would prevent the patient from rejecting the cells. With this scenario, functional ovarian tissue from donors could be used to engineer bioartificial ovaries for women with non-functioning ovaries.

The Wake Forest Baptist team isolated the two types of endocrine cells found in ovaries (theca and granulosa) from 21-day-old rats. The cells were encapsulated inside materials that are compatible with the body. The scientists evaluated three different ways of arranging the cells inside the capsules.

The function of the capsules was then evaluated in the lab by exposing them to follicle-stimulating hormone and luteinizing hormone, two hormones that stimulate ovaries to produce sex hormones. The arrangement of cells that most closely mimicked the natural ovary (layers of cells in a 3-D shape) secreted levels of estrogen that were 10 times higher than other cell arrangements.

The capsules also secreted progesterone as well as inhibin and activin, two hormones that interact with the pituitary and hypothalamus and are important to the body's natural system to regulate the production of female sex hormones.

"Cells in the multilayer capsules were observed to function in similar fashion to the native ovaries," said Opara. "The secretion of inhibin and activin secretion suggests that these structures could potentially function as an artificial ovary by synchronizing with the body's innate control system."

Opara said the next step in the research, already underway, is to evaluate the function of the ovarian structures in animals.

Opara's co-researchers were Sivanandane Sittadjody, Ph.D, Sunyoung Joo, M.D., Ph.D., James J. Yoo, M.D., Ph.D., and Anthony Atala, M.D., all from Wake Forest Baptist, and Justin M. Saul, Ph.D., a former Wake Forest Baptist researcher now at Miami University.

The study was supported, in part, by the National Institutes of Health (award #R01DK080897).

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The above story is reprinted from materials provided by Wake Forest Baptist Medical Center.

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Journal Reference:

  1. Sivanandane Sittadjody, Justin M. Saul, Sunyoung Joo, James J. Yoo, Anthony Atala, Emmanuel C. Opara. Engineered multilayer ovarian tissue that secretes sex steroids and peptide hormones in response to gonadotropins. Biomaterials, 2013; 34 (10): 2412 DOI: 10.1016/j.biomaterials.2012.11.059

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/z6ZUn40lAPE/130326151131.htm

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Helen Mirren up for best actress at Olivier awards

Mar 26 (Reuters) - Leading money winners on the 2013 PGATour on Monday (U.S. unless stated): 1. Tiger Woods $3,787,600 2. Brandt Snedeker $2,859,920 3. Matt Kuchar $2,154,500 4. Steve Stricker $1,820,000 5. Phil Mickelson $1,650,260 6. Hunter Mahan $1,553,965 7. John Merrick $1,343,514 8. Dustin Johnson $1,330,507 9. Russell Henley $1,313,280 10. Kevin Streelman $1,310,343 11. Keegan Bradley $1,274,593 12. Charles Howell III $1,256,373 13. Michael Thompson $1,254,669 14. Brian Gay $1,171,721 15. Justin Rose $1,155,550 16. Jason Day $1,115,565 17. Chris Kirk $1,097,053 18. ...

Source: http://news.yahoo.com/helen-mirren-best-actress-olivier-awards-123053057.html

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Monday, March 25, 2013

Israel Fires into Syria Following Golan Attack on Troops

Reuters
March 24, 2013

Israel said it fired into Syria on Sunday and destroyed a machinegun position in the Golan Heights from where shots had been fired at Israeli soldiers in a further spillover of the Syrian civil war along a tense front.

It was not immediately clear whether Israel held Syrian troops or rebels responsible for what a spokesman for Prime Minister Benjamin Netanyahu said had been a deliberate attack on Israeli patrols in the occupied territory.

Israeli forces ?destroyed a Syrian machine gun nest that fired twice in the last 24 hours on Israeli patrols operating to safeguard the border,? the spokesman, Ofir Gendelman, said on his Twitter page.

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This article was posted: Sunday, March 24, 2013 at 11:03 am

Tags: war





Source: http://www.infowars.com/israel-fires-into-syria-following-golan-attack-on-troops/

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